Welcome to the CSET Lab at the University of Michigan!
The Laboratory of Cell Signaling in Engineered Tissues (CSET) was established in 2003 under the direction of Professor Andy Putnam. Residing in the Department of Biomedical Engineering at the University of Michigan since 2009, our laboratory conducts both fundamental and applied research in the broad areas of cell and tissue engineering. Our fundamental biological research addresses how the mechano-chemical properties of the extracellular matrix (ECM) influence both normal and pathologic tissue morphogenesis, with a particular emphasis on identifying the signal transduction mechanisms that drive these processes in 3D. Our engineering efforts then seek to leverage this fundamental knowledge to inspire the design of “instructive materials” for applications in regenerative medicine and as model systems in which to study disease.
Recent Lab News
Help for a Scarred Heart
Poets and physicians alike know that a scarred heart can’t beat the way it used to, but the science of reprogramming cells offers hope – for the physical heart, at least. A team of U-M biomedical engineers has turned groups of cells typically found in scar tissue into colonies of beating heart cells. (Read story by the UM News Service.)
(see Kong, et al., Scientific Reports, 2013)
Engineering functional microvasculature (see Grainger, et al., Tissue Engineering: Part A, 2013)
The CSET Lab gratefully acknowledges funding from federal and state government agencies, private foundations, the University of Michigan, and philanthropy. Thank you for supporting our research in regenerative medicine.
Robert C. Leland, Jr. and Donna D. Leland Professorship in Biomedical Engineering and Cardiovascular Medicine